Development of a comprehensive hybrid capture based NGS assay for therapeutic stratification of genomic instability (GIS) driven tumors and clinical validation

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Signaling Pathways in the Pathogenesis of Barrett’s Esophagus and Esophageal Adenocarcinoma

Maslenkina K et al. Signaling Pathways in the Pathogenesis of Barrett’s Esophagus and Esophageal Adenocarcinoma. Int J Mol Sci 2023; May 26;24(11):9304. doi: 10.3390/ijms24119304

Mast Cells in Regeneration of the Skin in Burn Wound with Special Emphasis on Molecular Hydrogen Effect

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The Remodeling of Dermal Collagen Fibrous Structures in Mice under Zero Gravity: The Role of Mast Cells

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Response of an HER2-Mutated NSCLC Patient to Trastuzumab Deruxtecan and Monitoring of Plasma ctDNA Levels by Liquid Biopsy

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Genetic alterations affecting the C-terminus of cyclin D1 are recurrent events in mantle cell lymphoma

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A Formylglycine-Peptide for the Site-Directed Identification of Phosphotyrosine-Mimetic Fragments

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Recent Advances in Castleman Disease

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Acquired G2032R Resistance Mutation in ROS1 to Lorlatinib Therapy Detected with Liquid Biopsy

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Protease Profile of Tumor-Associated Mast Cells in Melanoma

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Pentafluorophosphato-Phenylalanines: Amphiphilic Phosphotyrosine Mimetics Displaying Fluorine-Specific Protein Interactions

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Carboxypeptidase A3-A Key Component of the Protease Phenotype of Mast Cells

Atiakshin D et al. Carboxypeptidase A3-A Key Component of the Protease Phenotype of Mast Cells. Cells 2022; Feb 6;11(3):570. doi: 10.3390/cells11030570

TP53 co-mutations as an independent prognostic factor in 2nd and further line therapy- EGFR mutated non-small cell lung cancer IV patients treated with osimertinib

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Mucoepidermoid carcinoma of the salivary glands revisited with special reference to histologic grading and CRTC1/3-MAML2 genotyping

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MSI testing : What’s new? What should be considered?

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Delta-Like Protein 3 Expression in Paired Chemonaive and Chemorelapsed Small Cell Lung Cancer Samples

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Deep learning approach to predict sentinel lymph node status directly from routine histology of primary melanoma tumours

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Expression of CD38 in Mast Cells: Cytological and Histotopographic Features

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Mechanisms of Systolic Cardiac Dysfunction in PP2A, PP5 and PP2AxPP5 Double Transgenic Mice

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Comparison of Resistance Spectra After First and Second Line Osimertinib Treatment Detected by Liquid Biopsy

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Combined histochemical approach in assessing tryptase expression in the mast cell population

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Protease profile of normal and neoplastic mast cells in the human bone marrow with special emphasis on systemic mastocytosis

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Histamine can be Formed and Degraded in the Human and Mouse Heart

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Identification of CTLA-4-Positive Cells in the Human Tonsil

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Protein Phosphatase 2A Improves Cardiac Functional Response to Ischemia and Sepsis

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Extracellular Vesicles and Their Role in the Spatial and Temporal Expansion of Tumor–Immune Interactions

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Twenty-Eight Cases of Extraocular Sebaceous Carcinoma: A Correlative Clinicopathological and Immunohistochemical Analysis of Extraocular Sebaceous Carcinomas and Benign Sebaceous Gland Tumors.

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Hidden Variables in Deep Learning Digital Pathology and Their Potential to Cause Batch Effects: Prediction Model Study

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TP53 mutations as AN independent prognostic factor in 2nd AND FURTHER line THERAPY – EGFR mutated Non-Small Cell Lung Cancer IV PATIENTS treated with Osimertinib

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Initial Characterization of Stressed Transgenic Mice With Cardiomyocyte-Specific Overexpression of Protein Phosphatase 2C

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Initial Characterization of Transgenic Mice Overexpressing Human Histamine H2 Receptors

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Pharmacological and physiological assessment of serotonin formation and degradation in isolated preparations from mouse and human hearts

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Development of the NOGGO GIS v1 Assay, a Comprehensive Hybrid-Capture-Based NGS Assay for Therapeutic Stratification of Homologous Repair Deficiency Driven Tumors and Clinical Validation

Willing, E.-M.; Vollbrecht, C.; Vössing, C.; Weist, P.; Schallenberg, S.; Herbst, J.M.; Schatz, S.; Jóri, B.; Bataillon, G.; Harter, P.;
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Liquid Biopsy for Biomarker Testing in Non-Small Cell Lung Cancer: A European Perspective

Umberto Malapelle 1 , Marcello Tiseo 2 , Ana Vivancos 3, Joshua Kapp 4, M. Josè Serrano 5,6,7, and Markus Tiemann 8,*. Liquid Biopsy for Biomarker Testing in Non-Small Cell Lung Cancer: A European Perspective. Molecular Pathology in Solid Tumors. 2021

Protease profile of normal and neoplastic mast cells in the human bone marrow with special emphasis on systemic mastocytosis

Dmitri Atiakshin  1   2 , Igor Buchwalow  3 , Peter Horny  4 , Markus Tiemann  5. Protease profile of normal and neoplastic mast cells in the human bone marrow with special emphasis on systemic mastocytosis. Histochem Cell Biol. 2021 May;155(5):561-580. doi: 10.1007/s00418-021-01964-3. Epub 2021 Jan 25. PMID: 33492488

Mucoepidermoid carcinoma of the salivary glands revisited with special reference to histologic grading and CRTC1/3-MAML2 genotyping

Fehr A. et al. Mucoepidermoid carcinoma of the salivary glands revisited with special reference to histologic grading and CRTC1/3-MAML2 genotyping. Virchows Arch. 2021 Nov;479(5):975-985. doi: 10.1007/s00428-021-03146-x. Epub 2021 Jul 7. PMID: 34231055

Comparison of Resistance Spectra after First and Second Line Osimertinib Treatment Detected by Liquid Biopsy

Jóri, B.; Schatz, S.; Kaller, L.; Kah, B.; Roeper, J.; Ramdani, H.O.; Diehl, L.; Hoffknecht, P.; Grohé, C.; Griesinger, F.; Tiemann, M.; Heukamp, L.C.; Falk, M. Comparison of Resistance Spectra after First and Second Line Osimertinib Treatment Detected by Liquid Biopsy. Cancers 2021, 13(12), 2861

Morbus Castleman – ein seltenes, heterogenes Krankheitsbild

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BRAF mutation functional class have no negative impact on the clinical outcome of advanced NSCLC and associate with susceptibility to immunotherapy

BRAF mutations and BRAF mutation functional class have no negative impact on the clinical outcome of advanced NSCLC and associate with susceptibility to immunotherapy. European Journal of Cancer 2021; DOI: 10.1016/j.ejca.2021.02.036

Renaissance of Radiotherapy in Intestinal Lymphoma? 10-Year Efficacy and Tolerance in Multimodal Treatment of 134 Patients: Follow-up of Two German Multicenter Consecutive Prospective Phase II Trials

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Influence of Biopsy Technique on Molecular Genetic Tumor Characterization in Non-Small Cell Lung Cancer-The Prospective, Randomized, Single-Blinded, Multicenter PROFILER Study Protocol

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Twenty-Eight Cases of Extraocular Sebaceous Carcinoma: A Correlative Clinicopathological and Immunohistochemical Analysis of Extraocular Sebaceous Carcinomas and Benign Sebaceous Gland Tumors

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Biological Characterization, Mechanistic Investigation and Structure-Activity Relationships of Chemically Stable TLR2 Antagonists

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Signal amplification in immunohistochemistry: loose-jointed deformable heteropolymeric HRP conjugates vs. linear polymer backbone HRP conjugates

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EGFR immunohistochemistry as biomarker for antibody-based therapy of squamous NSCLC – Experience from the first ring trial of the German Quality Assurance Initiative for Pathology (QuIP ®)

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Mast cells and collagen fibrillogenesis

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Multicolor immunofluorescence reveals that p63- and/or K5-positive progenitor cells contribute to normal breast epithelium and usual ductal hyperplasia but not to low-grade intraepithelial neoplasia of the breast

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Therapiestandards und Perspektiven beim nichtkleinzelligen Lungenkarzinom im Stadium IV

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Immunophenotyping of the PD-L1-positive cells in angioimmunoblastic T cell lymphoma and Hodgkin disease

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Characterization of mast cell populations using different methods for their identification

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Identification of autofluorescent cells in human angioimmunoblastic T-cell lymphoma

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The contribution of Paul Ehrlich to histochemistry: a tribute on the occasion of the centenary of his death

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Identification of a High-Level MET Amplification in CTCs and cfTNA of an ALK-Positive NSCLC Patient Developing Evasive Resistance to Crizotinib

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Detection of EGFR Variants in Plasma: A Multilaboratory Comparison of a Real-Time PCR EGFR Mutation Test in Europe

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Immunohistochemical distinction of ABC and GCB in extranodal DLBCL is not reflected in mutation patterns

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Multiple immunolabeling with antibodies from the same host species in combination with tyramide signal amplification

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Spatial analysis of p63, K5 and K7 defines two groups of progenitor cells that differentially contribute to the maintenance of normal sebaceous glands, extraocular sebaceous carcinoma and benign sebaceous tumors

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Favorable radiation field decrease in gastric marginal zone lymphoma : Experience of the German Study Group on Gastrointestinal Lymphoma (DSGL)

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Harmonization and Standardization of Panel-Based Tumor Mutational Burden Measurement: Real-World Results and Recommendations of the Quality in Pathology Study

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Interlaboratory concordance of PD-L1 immunohistochemistry for non-small-cell lung cancer

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Tryptase as a polyfunctional component of mast cells

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Mast cell chymase: morphofunctional characteristics

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Adenosquamous Carcinoma of the Pancreas Comprise a Heterogeneous Group of Tumors With the Worst Outcome: A Clinicopathological Analysis of 25 Cases Identified in 562 Pancreatic Carcinomas Resected With Curative Intent

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One-step nucleic acid amplification-a molecular method for the detection of lymph node metastases in breast cancer patients; results of the German study group

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Solid pseudopapillary neoplasms of the pancreas show an interruption of the Wnt-signaling pathway and express gene products of 11q

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Responsiveness of adjacent ductal carcinoma in situ and changes in HER2 status after neoadjuvant chemotherapy/trastuzumab treatment in early breast cancer–results from the GeparQuattro study (GBG 40)

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Solid pseudopapillary neoplasms of the pancreas are associated with FLI-1 expression, but not with EWS/FLI-1 translocation

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Lymphatic spread of ductal pancreatic adenocarcinoma is independent of lymphangiogenesis

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Final safety and efficacy analysis of a phase I/II trial with imatinib and vinorelbine for patients with metastatic breast cancer

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Squamous/epidermoid differentiation in normal breast and salivary gland tissues and their corresponding tumors originate from p63/K5/14-positive progenitor cells

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K5/K14-positive cells contribute to salivary gland-like breast tumors with myoepithelial differentiation

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BCL9L expression in pancreatic neoplasia with a focus on SPN: a possible explanation for the enigma of the benign neoplasia

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Integrated Analysis of PTEN and p4EBP1 Protein Expression as Predictors for pCR in HER2-Positive Breast Cancer

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Oxidative stress and NO generation in the rat pancreatitis induced by pancreatic duct ligation

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L-arginine-NO-cGMP signalling pathway in pancreatitis

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Cellular organization and histogenesis of adenosquamous carcinoma of the pancreas: evidence supporting the squamous metaplasia concept

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Immunohistochemical and molecular profile of salivary gland cancer in children

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Spatially correlated phenotyping reveals K5-positive luminal progenitor cells and p63-K5/14-positive stem cell-like cells in human breast epithelium

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New Insight into the Role of Nitric Oxide Pathways in Pancreas

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Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients

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A Novel EGFR(C797) Variant Detected in a Pleural Biopsy Specimen from an Osimertinib-Treated Patient Using a Comprehensive Hybrid Capture-Based Next-Generation Sequencing Assay

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Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors

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Harmonized PD-L1 immunohistochemistry for pulmonary squamous-cell and adenocarcinomas

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Targeted next-generation sequencing for TP53, RAS, BRAF, ALK and NF1 mutations in anaplastic thyroid cancer

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The GSK461364 PLK1 inhibitor exhibits strong antitumoral activity in preclinical neuroblastoma models

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ALKG1269A mutation as a potential mechanism of acquired resistance to crizotinib in an ALK-rearranged inflammatory myofibroblastic tumor

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RITA displays anti-tumor activity in medulloblastomas independent of TP53 status

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Concordance between Comprehensive Cancer Genome Profiling in Plasma and Tumor Specimens

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Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma

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Risk stratification of EGFR + lung cancer diagnosed with panel-based next-generation sequencing

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Integration of Tumor Mutation Burden and PD-L1 Testing in Routine Laboratory Diagnostics in Non-Small Cell Lung Cancer

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Integrated clinicomolecular characterization identifies RAS activation and CDKN2A deletion as independent adverse prognostic factors in cancer of unknown primary

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Mutational spectrum of acquired resistance to reversible versus irreversible EGFR tyrosine kinase inhibitors

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Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC

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TP53 co-mutations in EGFR mutated patients in NSCLC stage IV: A strong predictive factor of ORR, PFS and OS in EGFR mt+ NSCLC

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ALK immunohistochemistry positive, FISH negative NSCLC is infrequent, but associated with impaired survival following treatment with crizotinib

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Genomic Profiling Identifies Outcome-Relevant Mechanisms of Innate and Acquired Resistance to Third-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy in Lung Cancer

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Safety and Efficacy of Crizotinib in Patients With Advanced or Metastatic ROS1-Rearranged Lung Cancer (EUCROSS): A European Phase II Clinical Trial

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Personalized therapy based on sequential molecular analysis leads to 30 months of survival in a patient with diffuse unresectable gastric linitis plastica

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Clinical and Pathological Characteristics of KEAP1- and NFE2L2-Mutated Non-Small Cell Lung Carcinoma (NSCLC)

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Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients

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Interlaboratory concordance of PD-L1 immunohistochemistry for non-small-cell lung cancer

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Detection of Discrepant Driver Mutations in a Patient with Two Synchronous Primary Non-Small Cell Lung Cancers (NSCLCs) with Liquid Biopsy

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