Biological Characterization, Mechanistic Investigation and Structure-Activity Relationships of Chemically Stable TLR2 Antagonists
chemical synthesis, inflammation, molecular modeling, structure-based design, TLR selectivity, TLR Selektivität, Toll-like receptors, Toll-like Rezeptoren
Bermudez M, et al. Biological Characterization, Mechanistic Investigation and Structure-Activity Relationships of Chemically Stable TLR2 Antagonists. ChemMedChem 2020 Jul 20;15(14):1364-1371. doi: 10.1002/cmdc.202000060
Influence of Biopsy Technique on Molecular Genetic Tumor Characterization in Non-Small Cell Lung Cancer-The Prospective, Randomized, Single-Blinded, Multicenter PROFILER Study Protocol
Biopsie NSCLC, biopsy NSCLC, orceps biopsy, next generation sequencing (NGS), Next-Generation Sequencing (NGS), nNGM, PROFILER Studie, PROFILER Study, Targeted therapy, zielgerichtete Therapie
Haentschel M, et al. Influence of Biopsy Technique on Molecular Genetic Tumor Characterization in Non-Small Cell Lung Cancer-The Prospective, Randomized, Single-Blinded, Multicenter PROFILER Study Protocol. Diagnostics (Basel) 2020 Jul 6;10(7):459. doi: 10.3390/diagnostics10070459
Cellular organization and histogenesis of adenosquamous carcinoma of the pancreas: evidence supporting the squamous metaplasia concept
Adenosquamöses Karzinom, Adenosquamous carcinoma, Keratin, Keratins, Ki67, MUC1, MUC5AC, p40, p63, Transdifferenzierung
Boecker W, et al. Cellular organization and histogenesis of adenosquamous carcinoma of the pancreas: evidence supporting the squamous metaplasia concept. Histochem Cell Biol 2020 Jul;154(1):97-105. doi: 10.1007/s00418-020-01864-y
Mast cells and collagen fibrillogenesis
Collagen fibrillogenesis, Kollagenfibrogenese, Mast cells, Mastzelle
Atiakshin D, et al. Mast cells and collagen fibrillogenesis. Histochem Cell Biol 2020 Jul;154(1):21-40. DOI: 10.1007/s00418-020-01875-9
Harmonization and Standardization of Panel-Based Tumor Mutational Burden Measurement: Real-World Results and Recommendations of the Quality in Pathology Study
Gen Panel, Gene panel, Immuno-oncology, Immunonkologie, Lung cancer, Lungenkrebs, Qualitätssicherung, Quality assurance, Sequencing, Sequenzierung, tumor mutational burden (TMB), Tumormutationslast (TMB)
Stenzinger A, et al. Harmonization and Standardization of Panel-Based Tumor Mutational Burden Measurement: Real-World Results and Recommendations of the Quality in Pathology Study. J Thorac Oncol 2020 Jul;15(7):1177-1189. DOI: 10.1016/j.jtho.2020.01.023
Integration of Tumor Mutation Burden and PD-L1 Testing in Routine Laboratory Diagnostics in Non-Small Cell Lung Cancer
ARIDA1, Hybrid-Capture Next Generation Sequencing (NGS), immunotherapy, Immuntherapie, KEAP1, NOWEL, NSCLC, PD-L1, POLE, STK11, tumor mutational burden (TMB), Tumormutationslast (TMB)
Schatz S, et al. Integration of Tumor Mutation Burden and PD-L1 Testing in Routine Laboratory Diagnostics in Non-Small Cell Lung Cancer. Cancers 2020 Jun 24;12(6):1685. doi: 10.3390/cancers12061685
Integrated clinicomolecular characterization identifies RAS activation and CDKN2A deletion as independent adverse prognostic factors in cancer of unknown primary
Cancer of unknown primary (CUP), CDKN2A, FGFR4, NOTCH1, TP53
Bochtler T, et al. Integrated clinicomolecular characterization identifies RAS activation and CDKN2A deletion as independent adverse prognostic factors in cancer of unknown primary. Int J Cancer 2020 Jun 1;146(11):3053-3064. doi: 10.1002/ijc.32882. Epub 2020 Mar 11
Mutational spectrum of acquired resistance to reversible versus irreversible EGFR tyrosine kinase inhibitors
acquired resistance mechanisms, EGFR p.T790M, EGFR tyrosine kinase inhibitors (TKI), EGFR Tyrosinekinaseinhibitor (TKI), Her2 amplification, Her2 Amplifikation, MET amplification, MET Amplifikation, multiplexed targeted sequencing (NGS), Tumorresistenz
Wagener-Ryczek S, et al. Mutational spectrum of acquired resistance to reversible versus irreversible EGFR tyrosine kinase inhibitors. BMC Cancer 2020 May 12;20(1):408. doi: 10.1186/s12885-020-06920-3
Renaissance of Radiotherapy in Intestinal Lymphoma? 10-Year Efficacy and Tolerance in Multimodal Treatment of 134 Patients: Follow-up of Two German Multicenter Consecutive Prospective Phase II Trials
Extended field, ntestinal lymphoma, Intestinale Lymphome, Involved field, Involved site radiation therapy, Normal tissue complication probability, Radiotherapie Lymphome
Reinartz G, et al. Renaissance of Radiotherapy in Intestinal Lymphoma? 10-Year Efficacy and Tolerance in Multimodal Treatment of 134 Patients: Follow-up of Two German Multicenter Consecutive Prospective Phase II Trials. Oncologist 2020 May;25(5):e816-e832. doi: 10.1634/theoncologist.2019-0783
Adenosquamous Carcinoma of the Pancreas Comprise a Heterogeneous Group of Tumors With the Worst Outcome: A Clinicopathological Analysis of 25 Cases Identified in 562 Pancreatic Carcinomas Resected With Curative Intent
Adenosquamöses Karzinom des Pankreas, Adenosquamous carcinoma of the pancreas, ASCAP, K5/14, p63
Boecker W, et al. Adenosquamous Carcinoma of the Pancreas Comprise a Heterogeneous Group of Tumors With the Worst Outcome: A Clinicopathological Analysis of 25 Cases Identified in 562 Pancreatic Carcinomas Resected With Curative Intent. Pancreas 2020 May/Jun 2020;49(5):683-691. doi: 10.1097/MPA.0000000000001548