BRAF mutation functional class have no negative impact on the clinical outcome of advanced NSCLC and associate with susceptibility to immunotherapy
BRAF funktionale Klassen, BRAF mutation functional class, BRAF mutation subtype, BRAF zielgerichtete Therapie, BRAF-Mutated lung cancer, BRAF-Mutationssubtypen, BRAF-mutiertes Lungenkarzinom, BRAF-Targeted therapy,, NSCLC immunotherapy, NSCLC Immuntherapie
Wiesweg M, Preuß C, Roeper J, Metzenmacher M, Eberhardt W, Stropiep U, et al. BRAF mutations and BRAF mutation functional class have no negative impact on the clinical outcome of advanced NSCLC and associate with susceptibility to immunotherapy. Eur J Cancer 2021 May; DOI: 10.1016/j.ejca.2021.02.036
Identification of CTLA-4-Positive Cells in the Human Tonsil
antibodies, Antikörper, CTLA-4, immunophenotyping, Immunphänotypisierung, T-cell activation, T-lymphocytes, T-Lymphozyten, T-Zell Aktivierung, tonsil, Tonsille
Tiemann M, et al. Identification of CTLA-4-Positive Cells in the Human Tonsil. Cells 2021 Apr 27;10(5):1027. doi: 10.3390/cells10051027
Protein Phosphatase 2A Improves Cardiac Functional Response to Ischemia and Sepsis
Heart, Herz, Ischämie, ischemia, LPS, PP2A, protein phosphorylation, Protein Phosphorylierung, Sepsis, Transgene Mäuse, transgenic mice
Gergs U, et al. Protein Phosphatase 2A Improves Cardiac Functional Response to Ischemia and Sepsis. Int J Mol Sci 2021 Apr 23;23(9):4688. doi.org/10.3390/ijms23094688
Extracellular Vesicles and Their Role in the Spatial and Temporal Expansion of Tumor–Immune Interactions
angeborene Immunantwort, diagnostics, Diagnostik, extracellular vesicle, Extrazelluläre Vesikel, innate immune responses, Liquid Biopsy, microbiome, Mikrobiom, PD-L1, physical activity, physische Aktivität, tumor evolution, Tumor-Evolution, Tumor–Immun-Mikromilieu, tumor–immune microenvironment
Lipinski S, Tiemann K, Extracellular Vesicles and Their Role in the Spatial and Temporal Expansion of Tumor–Immune Interactions. Int J Mol Sci 2021 Apr;22(7): 3374. doi: 10.3390/ijms22073374
Neue Indikation PIK3CA-mutiertes Mammakarzinom: Erste Erfahrungen aus dem molekularpathologischen Routinelabor
Mamma carcinoma, Mammakarzinom myoepitheliale Differenzierung, next generation sequencing (NGS), Next-Generation Sequencing (NGS), PIK3CA
Strohkamp S, Schmidt S, Falk M, Tiemann K. Neue Indikation PIK3CA-mutiertes Mammakarzinom: Erste Erfahrungen aus dem molekularpathologischen Routinelabor. Journal Oncologie 2021
Hidden Variables in Deep Learning Digital Pathology and Their Potential to Cause Batch Effects: Prediction Model Study
Artefacte, artifacts, artificial intelligence, clinical pathology, convolutional neural networks, deep learning, digital pathology, digitale Pathologie, künstliche Intelligenz, machine learning, Maschinelles Lernen, neural networks, Neuronale Netzwerke, Pathologie, pathology, pitfalls
Schmitt M, et al .Hidden Variables in Deep Learning Digital Pathology and Their Potential to Cause Batch Effects: Prediction Model Study. J Med Internet Res 2021 Feb 2;23(2):e23436. doi: 10.2196/23436
Twenty-Eight Cases of Extraocular Sebaceous Carcinoma: A Correlative Clinicopathological and Immunohistochemical Analysis of Extraocular Sebaceous Carcinomas and Benign Sebaceous Gland Tumors.
Boecker W, et al. Twenty-Eight Cases of Extraocular Sebaceous Carcinoma: A Correlative Clinicopathological and Immunohistochemical Analysis of Extraocular Sebaceous Carcinomas and Benign Sebaceous Gland Tumors. Am J Dermatopathol 2021 Feb 1;43(2):93-102. doi: 10.1097/DAD.0000000000001667
TP53 mutations as AN independent prognostic factor in 2nd AND FURTHER line THERAPY – EGFR mutated Non-Small Cell Lung Cancer IV PATIENTS treated with Osimertinib
EGFR, NSCLC, Osimertinib, TKI, TP53 Mutation
Roeper J, et al. TP53 mutations as AN independent prognostic factor in 2nd AND FURTHER line THERAPY – EGFR mutated Non-Small Cell Lung Cancer IV PATIENTS treated with Osimertinib. Transl Lung Cancer Res 2021 Jan;11(1):4-13. doi: 10.21037/tlcr-21-754
Initial Characterization of Stressed Transgenic Mice With Cardiomyocyte-Specific Overexpression of Protein Phosphatase 2C
Entzündung, Fibrose, fibrosis, heart failure, Herzversagen, inflammation, PP2A, PP2C, Transgene Mäuse, transgenic mice
Bollmann P, et al. Initial Characterization of Stressed Transgenic Mice With Cardiomyocyte-Specific Overexpression of Protein Phosphatase 2C. Front Pharmacol 2021 Jan 11;11:591773. DOI: 10.3389/fphar.2020.591773
Risk stratification of EGFR + lung cancer diagnosed with panel-based next-generation sequencing
Adenokarzinom der Lunge EGFR, lung adenocarcinoma, next generation sequencing (NGS), Next-Generation Sequencing (NGS), non small cell lung cancer (NSCLC), NSCLC, TP53, tyrosine kinase inhibitor (TKI), yrosinekinaseinhibitor (TKI)
Christopoulos P, et al. Risk stratification of EGFR + lung cancer diagnosed with panel-based next-generation sequencing. Lung Cancer 2020 Oct;148:105-112. doi: 10.1016/j.lungcan.2020.08.007